Research record
CML treatment-free remission discussion
Some CML patients who have had a deep molecular response for a long time may discuss a carefully monitored TKI stop attempt, sometimes called treatment-free remission.
What this is
Some CML patients who have had a deep molecular response for a long time may discuss a carefully monitored TKI stop attempt, sometimes called treatment-free remission.
Why it may come up
- deep molecular response
- stable molecular response
- quality-of-life discussion
- clinical trial question
What not to assume
- Do not stop medicine without the leukemia team.
- Do not imply treatment-free remission equals guaranteed cure.
- Do not discuss monitoring schedules as instructions.
At a glance
CML treatment-free remission discussion
- Type
- Trial search
- Mutation result
- BCR-ABL / Philadelphia chromosome context
- Where
- Global
- Evidence status
- Source gives context
- Last checked
- 2026-05-21
What we know
- NCI describes clinical trial work studying TKI cessation in CML patients with stable molecular response.
- NCI's discontinuation discussion emphasizes careful monitoring and selected-patient context.
What is unclear
- Whether a specific patient is a candidate depends on exact response history, monitoring access, medicine history, and physician judgment.
- This is different from a transplant and different from being automatically cured.
Questions to ask
- Is treatment-free remission a recognized goal in this exact case?
- What molecular response depth and duration would be required before discussing it?
- How often would PCR monitoring happen if a supervised stop attempt were ever considered?
Related trial leads
NCI
Tyrosine kinase inhibitor cessation for chronic myeloid leukemia patients with stable molecular response
Supports the treatment-free remission research context for selected CML patients with stable molecular response.