Research record

Chronic myeloid leukemia / BCR-ABL source map

CML needs its own pathway because BCR-ABL/Philadelphia chromosome language, disease phase, response monitoring, and TKI discussions are central.

What this is

CML needs its own pathway because BCR-ABL/Philadelphia chromosome language, disease phase, response monitoring, and TKI discussions are central.

Why it may come up

  • chronic phase
  • accelerated phase
  • blast phase
  • TKI discussion
  • trial search

What not to assume

  • Do not provide dose, switching, or resistance-management guidance.

At a glance

Chronic myeloid leukemia / BCR-ABL source map

Used in care guidelinesThis is a commonly recognized treatment category.
Type
diagnostic-context
Mutation result
BCR-ABL / Philadelphia chromosome context
Where
Global
Evidence status
Source gives context
Last checked
2026-05-21

What we know

  • NCI has a dedicated CML Treatment PDQ patient summary.

What is unclear

  • TKI-by-country access and response-monitoring explainers are not built yet.

Questions to ask

  • Does the report document BCR-ABL or Philadelphia chromosome positivity?
  • Which phase is documented: chronic, accelerated, or blast phase?
  • What monitoring terms should the family understand before the next visit?