Research record
Clinical trial search strategy
A trial-search record that helps families ask better questions without treating a trial listing as proof that a study fits.
What this is
A trial-search record that helps families ask better questions without treating a trial listing as proof that a study fits.
Why it may come up
- before next treatment line
- after recurrence
- mutation-specific search
What not to assume
- Never say a user qualifies for a trial.
At a glance
Clinical trial search strategy
- Type
- Trial search
- Mutation result
- any
- Where
- Global
- Evidence status
- Source gives context
- Last checked
- 2026-05-20
What we know
- ClinicalTrials.gov and NCI trial sources can identify records that mention melanoma, mutations, drugs, or prior therapy.
- Registry text can lag or omit details.
What is unclear
- A trial listing never confirms that a study fits.
- Recruiting status must be confirmed by the trial team.
Questions to ask
- Should we search trials before starting the next treatment?
- Which terms should we search?
- Who can contact the trial team?
Related trial leads
NCT03973151
Study of HL-085 in NRAS Mutant Advanced Melanoma
Primary early clinical trial record for HL-085/tunlametinib in NRAS-mutant melanoma that has spread or cannot be removed easily.
NCT06008106
Comparing Tunlametinib Capsules and Combination Chemotherapy in Advanced NRAS-mutant Melanoma
Phase III comparator trial after prior immunotherapy; useful for duration-of-response and trial-timing questions.
NCT04835805
Belvarafenib alone or with cobimetinib or cobimetinib plus nivolumab in NRAS-mutant advanced melanoma
A sourced NRAS melanoma trial lead after anti-PD-1/PD-L1 therapy that may explain a remembered MEK/RAF plus PD-1 trial concept.
NCT03979651
Trametinib plus hydroxychloroquine in NRAS melanoma
NRAS melanoma research lead involving MEK inhibition and autophagy inhibition.
Related cohort stories
Lived experience only
Trial search terms that helped you find better conversations
Share search phrases, registry links, and questions that made trial conversations clearer.