Curated clinical source

Stage IV melanoma

A source-linked guide for melanoma that has spread, including whole-body treatment and trial questions.

Stage IV melanoma means melanoma has spread to distant parts of the body. Treatment conversations often involve systemic therapy, symptom-focused local treatment, trial search, and careful sequencing.

What to clarify

• Where has melanoma spread?
• Are there symptoms that need urgent local treatment such as radiation or surgery?
• What mutation results are available?
• Has prior immunotherapy, targeted therapy, chemotherapy, or radiation already been used?

Questions to ask

• What options are commonly discussed at this point, and what is the goal of each?
• Should clinical trials be searched before starting the next line of therapy?
• If prior PD-1/PD-L1 treatment failed, what changes about the next conversation?
• What would make the team stop or switch treatment?